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Backpacks these days are getting very high tech, with new materials and water bladders etc. That's all good but what happens when your $440 pack is full of gear, you're hiking down the trail and it just doesn't feel comfortable? We hear all about contour hugging design and all that but somehow it's killing your back.
My suggestion is to loosen the upper straps allowing 4-5 inches of space between the top of the pack and your back. Now your back can conform to its own shape rather than being forced to fit the pack. I met this kid in Nepal who was hiking in pain and fixed his problem in 1 minute.
When you go on a trip, look into the possibility of bringing your own bikes! That way you know they're perfectly sized for you, are in fine working order, and have all of the equipment you're used to. Sometimes it can make a huge difference in the enjoyability of your trip, and it usually doesn't cost much.